Publications
Publications
Structural insights in the GTP-driven monomerization and activation of a bacterial LRRK2 homologue using allosteric nanobodies.
Galicia, C., Guaitoli, G., Fislage, M., Gloeckner, CJ., Versées, W.
eLife 13:RP94503, 2024
YbiB: a novel interactor of the GTPase ObgE
Deckers B, Vercauteren S, De Kock V, Martin C, Lazar T, Herpels P, Dewachter L, Verstraeten N, Peeters E, Ballet S, Michiels J, Galicia C*, Versées W*
Nucleic Acids Research 51(7):3420-3435, 2023.
(*co-senior authors)
Nanobodies as allosteric modulators of Parkinson’s disease-associated LRRK2
Singh, RK, Soliman, A, Guaitoli, G, Störmer, E, von Zweydorf, F, Dal Maso, T, Oun, A, Van Rillaer, L, Schmidt, SH, Chatterjee, D, David, JA, Pardon, E, Schwartz, TU, Knapp, S, Kennedy, EJ, Steyaert, J, Herberg, FW, Kortholt, A, Gloeckner, CJ, Versées, W
Proc Natl Acad Sci U S A. 119(9):e2112712119, 2022.
A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations
Paesmans J*, Martin E*, Deckers B, Berghmans M, Sethi R, Loeys Y, Pardon E, Steyaert J, Verstreken P, Galicia Diaz Santana C@, Versées W@
(* CoFirst, @ Corresponding)
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies
Leemans M*, Galicia Diaz Santana C*, Deyaert E, Daems E, Krause L, Paesmans J, Pardon E, Steyaert J, Kortholt A, Sobott F, Klostermeier D, Versées W@
(* CoFirst, @ Corresponding)
TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model
Lüthy K, Mei D, Fischer B, De F, Swerts J, Paesmans J, Parrini E, Lubarr N, Meijer I, Mackenzie K, Lee W, Cittaro D, Aridon P, Schoovaerts N, Versées W@, Verstreken P@, CASARI G@, GUERRINI R@
(@ Corresponding)
A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover
Deyaert E*, Wauters L*, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, Petrovic A, Gallardo R, Nederveen-schippers L, Athanasopoulos P, Pots H, Van H, Sobott F, Gloeckner C, Efremov R, Kortholt A, Versées W@
(* CoFirst, @ Corresponding)
Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function
Fischer B*, Lüthy K*, Paesmans J*, De K, Maes I, Swerts J, Kuenen S, Uytterhoeven V, Verstreken P@°, Versées W@°
(* CoFirst, ° CoLast, @ Corresponding)